WARNING: Gastrointestinal hypomotility (reduced gastrointestinal movement) Clozapine may cause slowing down of bowel (intestine) function, which may result in blockage, perforation or tissue damage and cause reactions such as constipation; nausea with or without vomiting; tenderness or swelling of the stomach, or bloating; gas/wind; foul-smelling breath; stomach pains/spasms; leakage of diarrhoea or frequent and forceful bowel movements (poo); bowel urges with no resulting movements; weight loss due to lack of appetite; lower back pain; pain or pressure in your bottom and bleeding from the bottom. These can lead to extremely severe outcomes. Your doctor must monitor bowel function before prescribing and during your therapy with CLOPINE. It is extremely important to immediately advise your doctor, coordinator, pharmacist, or any other health professional, of any changes to your bowel movements. Myocarditis/pericarditis/cardiomyopathy CLOPINE may cause myocarditis (inflammation of heart muscle) and/or cardiomyopathy (heart muscle disease), either of which may be fatal. Another heart condition, pericarditis (inflammation of the sac surrounding the heart) which may be severe has also been reported in patients on clozapine.Please advise your doctor if you have, or previously had, any heart problems. Your doctor will monitor you during treatment. If required, your doctor may want to refer you to a cardiologist for further tests. If you feel any symptoms such as chest pain, speak to your doctor immediately.
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