BEFORE STARTING ON CLOPINE® Please tell your doctor if you: • Have a problem with your intestines or bowel, or severe constipation • Have a heart problem • Have circulatory (blood) or nervous system problems • Have uncontrolled epilepsy seizures • Have problems with alcohol or drug abuse • Have any other type of medical condition (including diseases of the bone marrow, blood, kidney or liver) • Have any allergies (including to clozapine or lactose) • Are unable to have blood tests • Have a history of low white blood cell counts • Are pregnant or plan to become pregnant • Are breastfeeding or plan to breastfeed • Will be in a hot environment or do a lot of vigorous exercise • Are taking any other medicines, vitamins or supplements (with or without a prescription) SMOKING AND CAFFEINE Do smoking and caffeine interfere with Clopine® treatment? Smoking and caffeine can have an impact on how Clopine® affects the body. A sudden change in usual smoking or coffee-drinking habits can also change the effects of Clopine®, as well as the dose required. • Before starting on Clopine®: please tell your doctor if you smoke and/or drink coffee. • During treatment with Clopine®: please tell your doctor if you are planning to stop smoking and/or change the number of caffeinated drinks consumed in a day. 06
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